Inside Cover: Selective Ruthenium-Catalyzed Alkylation of Indoles by Using Amines (Chem. Eur. J. 9/2010)
نویسندگان
چکیده
منابع مشابه
Selective alkylation of (hetero)aromatic amines with alcohols catalyzed by a ruthenium pincer complex.
A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst ...
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In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C-H activation methodology exhibits a broad substrate scope such as different substituted indoles, pyrroles, and other azoles. Further synthetic applications of the alkylation products can lead to more a...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2010
ISSN: 0947-6539
DOI: 10.1002/chem.201090034